Discover everything you need to know about testosterone treatment therapy (TRT) with our comprehensive FAQs. Whether you’re seeking insights on hypogonadism, TRT benefits, diagnostic methods or administration techniques, we’ve got you covered. Our expert advice and detailed explanations provide a clear path towards understanding and addressing your needs. 


What is testosterone treatment therapy (TRT)?

Testosterone replacement therapy (also known as hormone replacement therapy) involves replacing testosterone levels with an external form of testosterone. TRT is given to men who can’t make enough testosterone on their own for their health to be at its best. Hormone replacement therapy extends to other hormones such as thyroid stimulating hormone (TSH), dehydroepiandrosterone sulfate (DHEA) and growth hormone.

Do I need TRT?

To determine if you need TRT you need an in-depth analysis from your medical specialists. This will require your full medical history and blood tests. Our role is to help you determine which treatment is right for you.

How is hypogonadism (low testosterone) diagnosed?

Hypogonadism comes in two forms – primary and secondary. In primary hypogonadism the testicles don’t function properly. It’s diagnosed by low testosterone levels and elevated LH/FSH levels. This signifies that the brain is signalling the body to make testosterone but the body is not able to respond.

Secondary hypogonadism is more complex. It’s caused by drug use, stress, injury or endocrine disruption which can lead to issues with other hormones. Men with secondary hypogonadism have low levels of testosterone, luteinizing hormone (LH) and follicle stimulating hormone FSH. This means the brain is not sending the right signals for the body to make enough testosterone.

What causes low testosterone?

Low testosterone is caused by many factors. They include:

  • Age
  • Poor diet and lifestyle
  • Testicular injury
  • Pharmaceutical medications
  • Post-traumatic stress disorder (PTSD)
  • Anabolic steroid use
  • Psychological chronic stress
  • Chronic stress from injuries or ongoing chronic disease
What blood work do I need for TRT?

If you’re new to TRT or need to check your current hormone levels, we suggest the Sports BB4 from i-medical. At Primal Zone we offer this panel as a service and routinely use it for check-ups. This panel tests for:

  • Free and Total Testosterone, SHBG
  • E2, FSH/LH, Prolactin, Progesterone
  • Cortisol
  • Dehydroepiandrosterone sulfate (DHEAS)
  • Insulin-like growth factor (IGF-1) + growth hormone (GH)
  • Liver Function (LFT)
  • Kidney Function (UEC)
  • Cholesterol/TG/HDL/LDL
  • Glucose
  • Full Blood Count (FBC)
  • Iron Studies
  • Magnesium
  • Thyroid stimulating hormone (TSH) / Thyroid function tests (FT3 / FT4)
  • High Sensitivity C-reactive protein (CRP)

It’s important you talk to your doctor about any symptoms you’re experiencing with TRT or other treatments. Unusual symptoms will require more specific blood testing.

What forms is testosterone prescribed in?

In Australia testosterone is prescribed in the following forms:

  • Primoteston (Testosterone Enanthate) – injectable
  • Compounded Testosterone Enanthate – injectable
  • Compounded Testosterone Cypionate – injectable
  • Reandron – a longer acting injectable   
  • AndroGel – low concentration topical gel
What is Primoteston?

Primoteston is Testosterone Enanthate and comes loaded in 1ml syringes. It’s the most affordable and accessible form of testosterone in Australia outside of the pharmaceutical benefits scheme (PBS). If you’re interested in accessing Primoteston through the PBS we recommend visiting your GP for a referral to an endocrinologist.

Should I take finasteride or dutasteride?

Primal Zone does not recommend the use of Finasteride or Dutasteride as they cause permanent side effects known as post finasteride syndrome. A recent class action lawsuit against the drug’s maker found them guilty of knowing about the negative effects.

How do I administer Testosterone injections?

In order to maintain steady concentrations, Testosterone Enanthate or Testosterone Cypionate injections should be administered at least twice per week. The best sites of injection are the deltoid muscle (the main muscle of the shoulder) or ventrogluteal muscle (the high part of the hip).

What size syringes should I use?

The best syringes to use are 27g or 29g, 12mm (1/2”) insulin syringes. If you are particularly overweight and lack muscle development you may need a 16mm needle to reach adequate muscle depth.

Will TRT make me lose my hair?

TRT does not cause hair loss. However, TRT will speed up the process if you are already bald or if you have the genes for male pattern baldness.

Will I get acne on TRT?

The first few months of TRT will cause your hormones to fluctuate and this can cause acne. We recommend that you wear natural fibre clothing and use natural body wash while you wait for your hormones to adjust.

Will TRT help me build muscle?

TRT alone will not help you build muscle. To attain the desired outcomes, you must supplement your TRT treatment with strength training and a proper diet.

Does TRT cause sleep apnoea?

TRT does not cause sleep apnoea. TRT may worsen sleep apnoea if you have low testosterone and sleep apnoea due to obesity.

What are good sources of information on TRT?
What are peptides?

Peptides are proteins that signal the body to release growth hormones for muscle growth and repair. The most common peptide, CJC, is used in bodybuilding to enhance muscle growth, recovery, fat loss and endurance. 

Peptides present minimal risks when used correctly. They are most effective when combined with appropriate exercise, nutrition and lifestyle choices. Peptides can be taken orally or via injection and are customised to individual needs. Consulting a healthcare professional is essential due to potential risks such as allergies and hormonal imbalances.

How can sex pills help me with erectile dysfunction?

Sex pills offer a solution for men dealing with erectile dysfunction (ED) which is caused by factors such as age, weight, cardiovascular health or psychological issues. These pills enhance blood flow to the penis leading to improved sexual performance and harder erections. They are very effective with about 94% of users experiencing positive results. 

Sex pills may not be suitable for individuals with specific medical conditions, such as heart disease, eye disease or those on certain medications. Common side effects include headaches, flushes and indigestion, with rare instances of prolonged erections needing medical attention. 

What is medical cannabis used for?

Medicinal cannabis is derived from the cannabis plant. It contains cannabinoids like THC and CBD. THC provides relief but also induces a high, while CBD treats symptoms without intoxication. CBD is used to alleviate symptoms of various medical conditions including epilepsy, anxiety and insomnia. It’s also used to manage cancer symptoms and chronic pain for conditions like arthritis and back pain.

Medical cannabis needs to be used with caution as THC impacts driving for up to 8 hours, while CBD can cause drowsiness. It was legalised in Australia in 2016 and is regulated by the Therapeutic Goods Administration (TGA). It’s accessible through medical specialists.